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Metalloproteinases as targets for anti inflammatory drugs progress in inflammation research 1999th edition kindle edition by kevin mk bottomley editor david bradshaw editor john s nixon editor 0 more format kindle edition. Metalloproteinases as targets for anti inflammatory drugs progress in inflammation research 9783764358563 medicine health science books amazoncom. This volume describes recent research in the field of metalloproteinases a family of enzymes that can catalyze tissue degradation in particular their participation in autoimmune diseases such as rheumatoid arthritis reviewing the latest developments in metalloproteinase inhibitor design and the current status of clinical candidates. This volume describes recent research in the field of metalloproteinases a family of enzymes that can catalyze tissue degradation in particular their participation in autoimmune diseases such as rheumatoid arthritis reviewing the latest developments in metalloproteinase inhibitor design and the. Rheumatoid arthritis ra is a systemic inflammatory disease characterized by the destruction of joint tissues including cartilage and bone cartilage degradation is attributed to metalloproteinases mps that belong to matrix metalloproteinase family and a disintegrin and metalloprotease with thrombospondin type 1 motifs produced by inflamed joint tissues